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Janumet may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness, or feeling very weak or tired.

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Call your doctor at once if you have any of these serious side effects:

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Less serious this side effects may include:

• diarrhea, constipation, mild nausea, upset stomach;
• headache, weakness, back pain, joint or mucle pain; or
• cold symptoms such as runny or stuffy nose, sneezing, sore throat.

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